› 3mhw

X-ray diffraction
1.45Å resolution

The complex crystal Structure of Urokianse and 2-Aminobenzothiazole

Released:
DOI: 10.2210/pdb3mhw/pdb
PDB entry 3mhw coloured by chain, front view.
PDB entry 3mhw coloured by chain, side view.
PDB entry 3mhw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
Jiang L-G, Yu H-Y, Yuan C, Wang J-D, Chen L-Q, Meehan EJ, Huang Z-X, Huang M-D
Chin. J. Struct. Chem. 28 1427-1432 (2009)

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator chain B Chain: U
Molecule details ›
Chain: U
Length: 247 amino acids
Theoretical weight: 27.85 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00749 (Residues: 179-425; Coverage: 60%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand ABV 1 x ABV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: R3
Unit cell:
a: 121.276Å b: 121.276Å c: 43.136Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.205 0.234
Expression system: Komagataella pastoris

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