› 3mkp

X-ray diffraction
2.81Å resolution

Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin

Released:
DOI: 10.2210/pdb3mkp/pdb
PDB entry 3mkp coloured by chain, front view.
PDB entry 3mkp coloured by chain, side view.
PDB entry 3mkp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gherardi E, Chirgadze DY, Blundell TL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hepatocyte growth factor alpha chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 183 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P14210 (Residues: 28-210; Coverage: 26%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS
Carbohydrate polymer
3 bound ligands:
Ligand SO4 4 x SO4
Ligand EPE 4 x EPE
Ligand SGN 1 x SGN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P41212
Unit cell:
a: 129.73Å b: 129.73Å c: 118.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.261
Expression system: Komagataella pastoris

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