› 3mq4

X-ray diffraction
2.8Å resolution

Metabotropic glutamate receptor mGluR7 complexed with LY341495 antagonist

Released:
DOI: 10.2210/pdb3mq4/pdb
PDB entry 3mq4 coloured by chain, front view.
PDB entry 3mq4 coloured by chain, side view.
PDB entry 3mq4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, He H, Weigelt J, Edwards AM, Arrowsmith CH, Bountra C, Cossar D, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172106 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 7 Chain: A
Molecule details ›
Chain: A
Length: 481 amino acids
Theoretical weight: 53.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14831 (Residues: 37-513; Coverage: 54%)
Gene names: GPRC1G, GRM7, MGLUR7
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand Z99 1 x Z99
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 54.673Å b: 131.159Å c: 140.644Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.262 0.293
Expression system: Spodoptera frugiperda

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