› 3mqp

X-ray diffraction
2.24Å resolution

Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930

Released:
DOI: 10.2210/pdb3mqp/pdb
PDB entry 3mqp coloured by chain, front view.
PDB entry 3mqp coloured by chain, side view.
PDB entry 3mqp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guan R, Xiao R, Zhao L, Acton TB, Gelinas C, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171817 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-related protein A1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16548 (Residues: 1-151; Coverage: 86%)
Gene names: BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Phorbol-12-myristate-13-acetate-induced protein 1 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 2.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13794 (Residues: 19-43; Coverage: 46%)
Gene names: NOXA, PMAIP1
Sequence domains: Phorbol-12-myristate-13-acetate-induced

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 43.138Å b: 43.196Å c: 46.387Å
α: 90° β: 113.5° γ: 90°
R-values:
R R work R free
0.182 0.177 0.23
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links