› 3n0t

X-ray diffraction
2.45Å resolution

Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Released:
DOI: 10.2210/pdb3n0t/pdb
PDB entry 3n0t coloured by chain, front view.
PDB entry 3n0t coloured by chain, side view.
PDB entry 3n0t coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Khutoreskaya G, Seitova A, Crombet L, Cossar D, Pagannon S, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Hassell A, Shewchuk L, Haffner C, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 469 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHL4 (Residues: 28-492; Coverage: 99%)
Gene names: DPP2, DPP7, QPP
Sequence domains: Serine carboxypeptidase S28
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand OPY 4 x OPY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 80.546Å b: 130.5Å c: 125.075Å
α: 90° β: 102.28° γ: 90°
R-values:
R R work R free
0.221 0.218 0.26
Expression system: Spodoptera frugiperda

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