› 3n93

X-ray diffraction
2.5Å resolution

Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3

Released:
DOI: 10.2210/pdb3n93/pdb
PDB entry 3n93 coloured by chain, front view.
PDB entry 3n93 coloured by chain, side view.
PDB entry 3n93 coloured by chain, top view.
Source organisms:
Entry authors: Pal K, Swaminathan K, Pioszak AA, Xu HE

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero hexamer
hetero trimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-142561 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Corticotropin-releasing factor receptor 2; Maltose/maltodextrin-binding periplasmic protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 482 amino acids
Theoretical weight: 53.15 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 25-392; Coverage: 99%)
  • Canonical: Q13324 (Residues: 3-109; Coverage: 23%)
Gene names: CRF2R, CRH2R, CRHR2, JW3994, b4034, malE
Sequence domains:
Structure domains:
Urocortin-3 Chain: C
Molecule details ›
Chain: C
Length: 17 amino acids
Theoretical weight: 1.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q969E3 (Residues: 142-157; Coverage: 11%)
Gene names: SPC, UCN3
Sequence domains: Corticotropin-releasing factor family

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2221
Unit cell:
a: 54.278Å b: 208.513Å c: 212.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.266
Expression systems:
  • Escherichia coli
  • Not provided

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