› 3n96

X-ray diffraction
2.75Å resolution

Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1

Released:
DOI: 10.2210/pdb3n96/pdb
PDB entry 3n96 coloured by chain, front view.
PDB entry 3n96 coloured by chain, side view.
PDB entry 3n96 coloured by chain, top view.
Source organisms:
Entry authors: Pal K, Swaminathan K, Pioszak AA, Xu HE

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-142560 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Corticotropin-releasing factor receptor 2; Maltose/maltodextrin-binding periplasmic protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 482 amino acids
Theoretical weight: 53.15 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 25-392; Coverage: 99%)
  • Canonical: Q13324 (Residues: 3-109; Coverage: 23%)
Gene names: CRF2R, CRH2R, CRHR2, JW3994, b4034, malE
Sequence domains:
Structure domains:
Urocortin Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 17 amino acids
Theoretical weight: 1.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P55089 (Residues: 107-122; Coverage: 16%)
Gene name: UCN
Sequence domains: Corticotropin-releasing factor family

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 54.063Å b: 211.551Å c: 107.839Å
α: 90° β: 104.37° γ: 90°
R-values:
R R work R free
0.237 0.235 0.273
Expression systems:
  • Escherichia coli
  • Not provided

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