› 3nax

X-ray diffraction
1.75Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-phosphoinositide-dependent protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 36.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15530 (Residues: 66-362; Coverage: 53%)
Gene names: PDK1, PDPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MP7 1 x MP7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P1
Unit cell:
a: 44.668Å b: 44.943Å c: 42.204Å
α: 109.27° β: 90.5° γ: 62.43°
R-values:
R R work R free
0.166 0.164 0.195
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer.
Fyffe et al. (2013)
6 more

14 mentions without citation

Forcefield_PTM: Ab Initio Charge and AMBER Forcefield Parameters for Frequently Occurring Post-Translational Modifications.
Khoury et al. (2013)
13 more