› 3nfk

X-ray diffraction
1.43Å resolution

Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of a rabies virus G protein

Released:
DOI: 10.2210/pdb3nfk/pdb
PDB entry 3nfk coloured by chain, front view.
PDB entry 3nfk coloured by chain, side view.
PDB entry 3nfk coloured by chain, top view.
Source organisms:
Primary publication:
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.
Babault N, Cordier F, Lafage M, Cockburn J, Haouz A, Prehaud C, Rey FA, Delepierre M, Buc H, Lafon M, Wolff N
Structure 19 1518-24 (2011)
PMID: 22000519

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-137109 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29074 (Residues: 499-604; Coverage: 11%)
Gene name: PTPN4
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Glycoprotein Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.48 KDa
Source organism: Lyssavirus rabies
Expression system: Not provided
UniProt:
  • Canonical: P03524 (Residues: 512-524; Coverage: 3%)
Gene name: G

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 53.43Å b: 53.7Å c: 81.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.204
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

7 review citations

Rabies.
Fooks et al. (2017)
6 more

5 mentions without citation

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.
Maisonneuve et al. (2016)
4 more