› 3noa

X-ray diffraction
1.98Å resolution

Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist

Released:
DOI: 10.2210/pdb3noa/pdb
PDB entry 3noa coloured by chain, front view.
PDB entry 3noa coloured by chain, side view.
PDB entry 3noa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Peng YH, Wu JS, Wu SY

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 5BC 2 x 5BC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 55.404Å b: 87.744Å c: 57.674Å
α: 90° β: 90.73° γ: 90°
R-values:
R R work R free
0.233 0.231 0.275
Expression system: Escherichia coli

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