› 3nr2

X-ray diffraction
2.9Å resolution

Crystal structure of Caspase-6 zymogen

Released:
DOI: 10.2210/pdb3nr2/pdb
PDB entry 3nr2 coloured by chain, front view.
PDB entry 3nr2 coloured by chain, side view.
PDB entry 3nr2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.
Wang XJ, Cao Q, Liu X, Wang KT, Mi W, Zhang Y, Li LF, LeBlanc AC, Su XD
EMBO Rep 11 841-7 (2010)
PMID: 20890311

Function and Biology Details

Reaction catalysed: 
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 33.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55212 (Residues: 24-293; Coverage: 92%)
Gene names: CASP6, MCH2
Sequence domains: Caspase domain
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P6522
Unit cell:
a: 127.983Å b: 127.983Å c: 167.912Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.179 0.237
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Huntington's disease: from molecular pathogenesis to clinical treatment.
Ross et al. (2011)
9 more

11 mentions without citation

Small Molecule Active Site Directed Tools for Studying Human Caspases.
Poreba et al. (2015)
10 more