› 3nrm

X-ray diffraction
3.05Å resolution

Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors

Released:
DOI: 10.2210/pdb3nrm/pdb
PDB entry 3nrm coloured by chain, front view.
PDB entry 3nrm coloured by chain, side view.
PDB entry 3nrm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Belanger DB, Curran PJ, Hruza A, Voigt J, Meng Z, Mandal AK, Siddiqui MA, Basso AD, Gray K
Bioorg Med Chem Lett 20 5170-4 (2010)
PMID: 20674350

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 32.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14965 (Residues: 126-403; Coverage: 69%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NRM 1 x NRM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P6122
Unit cell:
a: 81.89Å b: 81.89Å c: 169.271Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.258
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications.
Goel et al. (2015)
1 more