› 3nsq

X-ray diffraction
2.6Å resolution

Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron

Released:
DOI: 10.2210/pdb3nsq/pdb
PDB entry 3nsq coloured by chain, front view.
PDB entry 3nsq coloured by chain, side view.
PDB entry 3nsq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
Zhang H, Zhou R, Li L, Chen J, Chen L, Li C, Ding H, Yu L, Hu L, Jiang H, Shen X
J Biol Chem 286 1868-75 (2011)
PMID: 21084305

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand CHZ 1 x CHZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 115.026Å b: 99.924Å c: 47.201Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.265 0.318
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Regulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sites.
Zhang et al. (2015)
10 more

7 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
6 more