› 3nv1

X-ray diffraction
1.5Å resolution

Crystal structure of human galectin-9 C-terminal CRD

Released:
DOI: 10.2210/pdb3nv1/pdb
PDB entry 3nv1 coloured by chain, front view.
PDB entry 3nv1 coloured by chain, side view.
PDB entry 3nv1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose.
Yoshida H, Teraoka M, Nishi N, Nakakita S, Nakamura T, Hirashima M, Kamitori S
J Biol Chem 285 36969-76 (2010)
PMID: 20861009

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126137 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-9 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00182 (Residues: 218-355; Coverage: 39%)
Gene name: LGALS9
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P63
Unit cell:
a: 70.585Å b: 70.585Å c: 50.136Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.181 0.205
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Multifarious roles of sialic acids in immunity.
Varki et al. (2012)
11 more

3 mentions without citation

X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose.
Yoshida et al. (2010)
2 more