3o4l

X-ray diffraction
2.54Å resolution

Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-134740 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WLS4 (Residues: 25-300; Coverage: 94%)
Gene name: HLA-A
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
mRNA export factor ICP27 homolog Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 920 Da
Source organism: human gammaherpesvirus 4
UniProt:
  • Canonical: Q3KSU1 (Residues: 300-308; Coverage: 2%)
Gene names: BMLF1, BSLF2
T cell receptor alpha chain constant Chain: D
Molecule details ›
Chain: D
Length: 195 amino acids
Theoretical weight: 21.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01848 (Residues: 1-90; Coverage: 64%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
Structure domains: Immunoglobulins
T cell receptor beta constant 1 Chain: E
Molecule details ›
Chain: E
Length: 245 amino acids
Theoretical weight: 27.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 94.08Å b: 122.5Å c: 82.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.221 0.296