› 3o4r

X-ray diffraction
1.7Å resolution

Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4)

Released:
DOI: 10.2210/pdb3o4r/pdb
PDB entry 3o4r coloured by chain, front view.
PDB entry 3o4r coloured by chain, side view.
PDB entry 3o4r coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Bhatia C, Krojer T, Vollmar M, Yue WW, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189726 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dehydrogenase/reductase SDR family member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 261 amino acids
Theoretical weight: 27.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BTZ2 (Residues: 19-278; Coverage: 94%)
Gene names: DHRS4, SDR25C2, UNQ851/PRO1800
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
3 bound ligands:
Ligand EDO 4 x EDO
Ligand EPE 1 x EPE
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 60.07Å b: 132.2Å c: 133.796Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.25
Expression system: Escherichia coli

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