› 3o8v

X-ray diffraction
2.5Å resolution

Crystal Structure of the Tudor Domains from FXR1

Released:
DOI: 10.2210/pdb3o8v/pdb
PDB entry 3o8v coloured by chain, front view.
PDB entry 3o8v coloured by chain, side view.
PDB entry 3o8v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J
PLoS One 5 e13559 (2010)
PMID: 21072162

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156289 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein FXR1 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51114 (Residues: 2-132; Coverage: 21%)
Gene name: FXR1
Sequence domains:
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: R3
Unit cell:
a: 71.857Å b: 71.857Å c: 94.055Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.218 0.261
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Molecular mechanisms of fragile X syndrome: a twenty-year perspective.
Santoro et al. (2012)
9 more

3 mentions without citation

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.
Bian et al. (2011)
2 more