› 3of0

X-ray diffraction
2.7Å resolution

crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain

Released:
DOI: 10.2210/pdb3of0/pdb
PDB entry 3of0 coloured by chain, front view.
PDB entry 3of0 coloured by chain, side view.
PDB entry 3of0 coloured by chain, top view.
Source organism: Gallus gallus
Entry authors: Boubeva R, Pernot L, Perozzo R, Scapozza L

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P1
Unit cell:
a: 42.072Å b: 63.496Å c: 74.126Å
α: 78.66° β: 89.41° γ: 90°
R-values:
R R work R free
0.235 0.233 0.262
Expression system: Escherichia coli

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