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X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234821 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
T cell receptor beta chain Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 255 amino acids
Theoretical weight: 28.61 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Structure domains: Immunoglobulins
Pre T-cell antigen receptor alpha Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 130 amino acids
Theoretical weight: 13.39 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6ISU1 (Residues: 17-135; Coverage: 43%)
Gene name: PTCRA
Sequence domains: Pre-T-cell antigen receptor
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3221
Unit cell:
a: 114.902Å b: 114.902Å c: 183.101Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.175 0.24
Expression system: Trichoplusia ni

Quick links

Citations

12 review citations

How the TCR balances sensitivity and specificity for the recognition of self and pathogens.
Morris et al. (2012)
11 more

8 mentions without citation

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination.
Brazin et al. (2015)
7 more