3og4

X-ray diffraction
2.16Å resolution

The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-184842 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon lambda-1 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IU54 (Residues: 23-200; Coverage: 98%)
Gene names: IFNL1, IL29, ZCYTO21
Sequence domains: Interleukin-28A
Structure domains: Interferon lambda
Interferon lambda receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 226 amino acids
Theoretical weight: 25.32 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8IU57 (Residues: 19-226; Coverage: 41%)
Gene names: IFNLR1, IL28RA, LICR2
Sequence domains: Tissue factor
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 130.19Å b: 65.44Å c: 73.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.24
Expression systems:
  • Escherichia coli
  • Drosophila melanogaster