› 3ohl

X-ray diffraction
2.36Å resolution

catalytic domain of stromelysin-1 in complex with N-Hydroxy-2-(4-methoxy-N-(pyridine-3-ylmethyl)phenylsulfonamido)acetamide

Released:
DOI: 10.2210/pdb3ohl/pdb
PDB entry 3ohl coloured by chain, front view.
PDB entry 3ohl coloured by chain, side view.
PDB entry 3ohl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kowatz T, Naismith JH

Function and Biology Details

Reaction catalysed: 
Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-140079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromelysin-1 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08254 (Residues: 100-266; Coverage: 36%)
Gene names: MMP3, STMY1
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

4 bound ligands:
Ligand CA 3 x CA
Ligand ZN 2 x ZN
Ligand OHL 1 x OHL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2221
Unit cell:
a: 56.964Å b: 120.512Å c: 46.627Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.261 0.283
Expression system: Escherichia coli BL21(DE3)

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