› 3ooy

X-ray diffraction
2.05Å resolution

Crystal structure of human Transketolase (TKT)

Released:
DOI: 10.2210/pdb3ooy/pdb
PDB entry 3ooy coloured by chain, front view.
PDB entry 3ooy coloured by chain, side view.
PDB entry 3ooy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Krojer T, Krysztofinska E, Guo K, Pilka E, Kochan G, Chaikuad A, Vollmar M, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Kavanagh K, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transketolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 616 amino acids
Theoretical weight: 67.2 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P29401 (Residues: 10-620; Coverage: 98%)
Gene name: TKT
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand TPP 2 x TPP
3 bound ligands:
Ligand CA 2 x CA
Ligand ACT 3 x ACT
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P61
Unit cell:
a: 117.23Å b: 117.23Å c: 176.803Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.234
Expression system: Trichoplusia ni

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