› 3osk

X-ray diffraction
1.8Å resolution

Crystal structure of human CTLA-4 apo homodimer

Released:
DOI: 10.2210/pdb3osk/pdb
PDB entry 3osk coloured by chain, front view.
PDB entry 3osk coloured by chain, side view.
PDB entry 3osk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
Yu C, Sonnen AF, George R, Dessailly BH, Stagg LJ, Evans EJ, Orengo CA, Stuart DI, Ladbury JE, Ikemizu S, Gilbert RJ, Davis SJ
J Biol Chem 286 6685-96 (2011)
PMID: 21156796

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic T-lymphocyte protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 13.98 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16410 (Residues: 36-161; Coverage: 67%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 43.864Å b: 51.457Å c: 102.849Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.2 0.275
Expression system: Cricetulus griseus

Quick links

Citations

5 review citations

Confusing signals: recent progress in CTLA-4 biology.
Walker et al. (2015)
4 more

25 mentions without citation

CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.
Sobhani et al. (2021)
24 more