› 3ovl

X-ray diffraction
1.81Å resolution

Structure of an amyloid forming peptide VQIVYK from the TAU protein in complex with orange G

Released:
DOI: 10.2210/pdb3ovl/pdb
PDB entry 3ovl coloured by chain, front view.
PDB entry 3ovl coloured by chain, side view.
PDB entry 3ovl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Towards a pharmacophore for amyloid.
Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D
PLoS Biol 9 e1001080 (2011)
PMID: 21695112

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 750 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 623-628; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand ACY 1 x ACY
Ligand ORA 1 x ORA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 55.056Å b: 4.831Å c: 22.127Å
α: 90° β: 102.98° γ: 90°
R-values:
R R work R free
0.259 0.259 0.259
Expression system: Not provided

Quick links

Citations

25 review citations

Structural Studies of Amyloid Proteins at the Molecular Level.
Eisenberg et al. (2017)
24 more

11 mentions without citation

NMR Meets Tau: Insights into Its Function and Pathology.
Lippens et al. (2016)
10 more