› 3oz0

X-ray diffraction
3Å resolution

PPAR Delta in complex with azppard02

Released:
DOI: 10.2210/pdb3oz0/pdb
PDB entry 3oz0 coloured by chain, front view.
PDB entry 3oz0 coloured by chain, side view.
PDB entry 3oz0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Luckhurst CA, Stein LA, Furber M, Webb N, Ratcliffe MJ, Allenby G, Botterell S, Tomlinson W, Martin B, Walding A
Bioorg Med Chem Lett 21 492-6 (2011)
PMID: 21094606

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 165-441; Coverage: 63%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 3OZ 1 x 3OZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 113.258Å b: 49.134Å c: 58.574Å
α: 90° β: 105.34° γ: 90°
R-values:
R R work R free
0.224 0.215 0.27
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.
Wu et al. (2017)
8 more

2 mentions without citation

Activation of PPARδ: from computer modelling to biological effects.
Kahremany et al. (2015)
1 more