› 3p08

X-ray diffraction
2.3Å resolution

Crystal structure of the human BTK kinase domain

Released:
DOI: 10.2210/pdb3p08/pdb
PDB entry 3p08 coloured by chain, front view.
PDB entry 3p08 coloured by chain, side view.
PDB entry 3p08 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yu CL, Hymowitz SG

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chains: A, B
Molecule details ›
Chains: A, B
Length: 267 amino acids
Theoretical weight: 31.21 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 393-659; Coverage: 41%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 46.602Å b: 103.493Å c: 117.564Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.222 0.278
Expression system: Spodoptera frugiperda

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