› 3p1a

X-ray diffraction
1.7Å resolution

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

Released:
DOI: 10.2210/pdb3p1a/pdb
PDB entry 3p1a coloured by chain, front view.
PDB entry 3p1a coloured by chain, side view.
PDB entry 3p1a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Eswaran J, Fedorov O, Cooper CDO, Kroeler T, Vollmar M, Krojer T, Berridge G, Muniz JRC, Pike ACW, von Delft F, Weigelt J, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99640 (Residues: 75-362; Coverage: 58%)
Gene names: MYT1, PKMYT1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 10 x EDO
Ligand DMS 2 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 45.4Å b: 56.3Å c: 114.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.15 0.195
Expression system: Escherichia coli

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