› 3p3y

X-ray diffraction
2.6Å resolution

Crystal structure of neurofascin homophilic adhesion complex in space group p6522

Released:
DOI: 10.2210/pdb3p3y/pdb
PDB entry 3p3y coloured by chain, front view.
PDB entry 3p3y coloured by chain, side view.
PDB entry 3p3y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules.
Liu H, Focia PJ, He X
J Biol Chem 286 797-805 (2011)
PMID: 21047790

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurofascin Chain: A
Molecule details ›
Chain: A
Length: 404 amino acids
Theoretical weight: 45.29 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O94856 (Residues: 25-428; Coverage: 31%)
Gene names: KIAA0756, NFASC
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P6522
Unit cell:
a: 171.425Å b: 171.425Å c: 87.792Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.274 0.258 0.288
Expression system: Trichoplusia ni

Quick links

Citations

8 review citations

Contactins: structural aspects in relation to developmental functions in brain disease.
Zuko et al. (2011)
7 more

13 mentions without citation

Homophilic interaction of the L1 family of cell adhesion molecules.
Wei et al. (2012)
12 more