› 3p4l

X-ray diffraction
1.8Å resolution

Crystal structure of a hemojuvelin-binding fragment of neogenin

Released:
DOI: 10.2210/pdb3p4l/pdb
PDB entry 3p4l coloured by chain, front view.
PDB entry 3p4l coloured by chain, side view.
PDB entry 3p4l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å.
Yang F, West AP, Bjorkman PJ
J Struct Biol 174 239-44 (2011)
PMID: 20971194

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187786 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neogenin Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 23.9 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q92859 (Residues: 853-1054; Coverage: 14%)
Gene names: IGDCC2, NEO1, NGN
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 52.581Å b: 112.921Å c: 80.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.234
Expression system: Trichoplusia ni

Quick links

Citations

3 review citations

Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.
Tian et al. (2013)
2 more

5 mentions without citation

The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans.
Tian et al. (2013)
4 more