Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- RNA recognition motif domain
- Cleavage/polyadenylation specificity factor subunit 5
- RNA-binding domain superfamily
- Cleavage and polyadenylation specificity factor subunit 6, RNA recognition motif
- CPSF6/7 family
- Nucleotide-binding alpha-beta plait domain superfamily
- NUDIX hydrolase-like domain superfamily
- NUDIX hydrolase domain
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
mRNA cleavage factor I(m) complex, CPSF6 variant (preferred)
PDBe Complex ID:
PDB-CPX-129134 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cleavage and polyadenylation specificity factor subunit 5
Molecule details ›
Chains: A, B, C, D, E, F
Length: 202 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Nucleotide hydrolase
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase
Length: 202 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O43809 (Residues: 34-227; Coverage: 86%)
Sequence domains: Nucleotide hydrolase
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase
Cleavage and polyadenylation specificity factor subunit 6
Molecule details ›
Chains: L, M, N, O, P, Q
Length: 90 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
Length: 90 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q16630 (Residues: 80-161; Coverage: 15%)
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
BSRF BEAMLINE 3W1A
Spacegroup:
C2
Expression system: Escherichia coli
