› 3p6g

X-ray diffraction
1.2Å resolution

Human adipocyte lipid-binding protein FABP4 in complex with (R)-ibuprofen

Released:
DOI: 10.2210/pdb3p6g/pdb
PDB entry 3p6g coloured by chain, front view.
PDB entry 3p6g coloured by chain, side view.
PDB entry 3p6g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).
González JM, Fisher SZ
Acta Crystallogr F Struct Biol Commun 71 163-70 (2015)
PMID: 25664790

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, adipocyte Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15090 (Residues: 1-132; Coverage: 100%)
Gene name: FABP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand IZP 1 x IZP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 32.29Å b: 53.546Å c: 74.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.194
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Impact of Intracellular Lipid Binding Proteins on Endogenous and Xenobiotic Ligand Metabolism and Disposition.
Yabut et al. (2023)
5 other articles

3 mentions without citation

Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).
González et al. (2015)
2 more