Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- Leucine carboxyl methyltransferase 1
- Metallo-dependent phosphatase-like
- Methyltransferase Ppm1/Ppm2/Tcmp
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159231 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leucine carboxyl methyltransferase 1
Molecule details ›
Chain: T
Length: 334 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Leucine carboxyl methyltransferase
Structure domains: Vaccinia Virus protein VP39
Length: 334 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9UIC8 (Residues: 1-334; Coverage: 100%)
Sequence domains: Leucine carboxyl methyltransferase
Structure domains: Vaccinia Virus protein VP39
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chain: C
Length: 304 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Heliothis
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 304 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Heliothis
UniProt:
- Canonical: P67775 (Residues: 1-309; Coverage: 98%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
