› 3p7g

X-ray diffraction
1.5Å resolution

Structure of the human Langerin carbohydrate recognition domain in complex with mannose

Released:
DOI: 10.2210/pdb3p7g/pdb
PDB entry 3p7g coloured by chain, front view.
PDB entry 3p7g coloured by chain, side view.
PDB entry 3p7g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.
Chatwell L, Holla A, Kaufer BB, Skerra A
Mol Immunol 45 1981-94 (2008)
PMID: 18061677

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193804 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 4 member K Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 146 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJ71 (Residues: 193-328; Coverage: 42%)
Gene names: CD207, CLEC4K
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand MAN 4 x MAN
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P42
Unit cell:
a: 79.71Å b: 79.71Å c: 89.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.172 0.207
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The repertoire of glycan determinants in the human glycome.
Cummings RD. (2009)
8 more

5 mentions without citation

Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin.
Valverde et al. (2020)
4 more