› 3p8h

X-ray diffraction
2.55Å resolution

Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist

Released:
DOI: 10.2210/pdb3p8h/pdb
PDB entry 3p8h coloured by chain, front view.
PDB entry 3p8h coloured by chain, side view.
PDB entry 3p8h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Small-molecule ligands of methyl-lysine binding proteins.
Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV
J Med Chem 54 2504-11 (2011)
PMID: 21417280

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 323 amino acids
Theoretical weight: 37.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y468 (Residues: 268-590; Coverage: 39%)
Gene names: KIAA0681, L3MBT, L3MBTL, L3MBTL1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

3 bound ligands:
Ligand P8H 2 x P8H
Ligand SO4 3 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P32
Unit cell:
a: 106.264Å b: 106.264Å c: 90.144Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.242
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

28 review citations

Epigenetic protein families: a new frontier for drug discovery.
Arrowsmith et al. (2012)
27 more

10 mentions without citation

Readout of epigenetic modifications.
Patel et al. (2013)
9 more