› 3pdy

X-ray diffraction
2.22Å resolution

Structure of the third and fourth spectrin repeats of the plakin domain of plectin

Released:
DOI: 10.2210/pdb3pdy/pdb
PDB entry 3pdy coloured by chain, front view.
PDB entry 3pdy coloured by chain, side view.
PDB entry 3pdy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat.
Ortega E, Buey RM, Sonnenberg A, de Pereda JM
J Biol Chem 286 12429-38 (2011)
PMID: 21288893

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plectin Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 24.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15149 (Residues: 653-858; Coverage: 4%)
Gene names: PLEC, PLEC1
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P21212
Unit cell:
a: 97.42Å b: 119.4Å c: 44.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Spectraplakins: master orchestrators of cytoskeletal dynamics.
Suozzi et al. (2012)
13 more

5 mentions without citation

The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat.
Ortega et al. (2011)
4 more