› 3pe0

X-ray diffraction
2.95Å resolution

Structure of the central region of the plakin domain of plectin

Released:
DOI: 10.2210/pdb3pe0/pdb
PDB entry 3pe0 coloured by chain, front view.
PDB entry 3pe0 coloured by chain, side view.
PDB entry 3pe0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat.
Ortega E, Buey RM, Sonnenberg A, de Pereda JM
J Biol Chem 286 12429-38 (2011)
PMID: 21288893

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plectin Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15149 (Residues: 750-1028; Coverage: 6%)
Gene names: PLEC, PLEC1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR-H
Spacegroup: P212121
Unit cell:
a: 72.65Å b: 108.512Å c: 112.139Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.241 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Spectraplakins: master orchestrators of cytoskeletal dynamics.
Suozzi et al. (2012)
13 more

5 mentions without citation

The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat.
Ortega et al. (2011)
4 more