› 3pe6

X-ray diffraction
1.35Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolyzes glycerol monoesters of long-chain fatty acids
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monoglyceride lipase Chain: A
Molecule details ›
Chain: A
Length: 303 amino acids
Theoretical weight: 33.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q99685 (Residues: 1-303; Coverage: 100%)
Gene name: MGLL
Sequence domains: Serine aminopeptidase, S33
Structure domains: alpha/beta hydrolase

Ligands and Environments

1 bound ligand:
Ligand ZYH 1 x ZYH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 93.947Å b: 128.145Å c: 60.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.115 0.114 0.147
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

The Lid Domain in Lipases: Structural and Functional Determinant of Enzymatic Properties.
Khan et al. (2017)
4 more

27 mentions without citation

Monoglyceride lipase: Structure and inhibitors.
Scalvini et al. (2016)
26 more