› 3peg

X-ray diffraction
2.52Å resolution

Crystal structure of Neurofibromins Sec14-PH module containing a patient derived duplication (TD)

Released:
DOI: 10.2210/pdb3peg/pdb
PDB entry 3peg coloured by chain, front view.
PDB entry 3peg coloured by chain, side view.
PDB entry 3peg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.
Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K
Hum Mutat 32 191-7 (2011)
PMID: 21089070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-149213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurofibromin Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21359 (Residues: 1566-1733, 1721-1837; Coverage: 10%)
Gene name: NF1
Sequence domains: Divergent CRAL/TRIO domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 5 x SO4
Ligand MG 1 x MG
Ligand PEV 1 x PEV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P6422
Unit cell:
a: 104.6Å b: 104.6Å c: 116.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.223 0.264
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms.
Carroll SL. (2012)
3 more

4 mentions without citation

Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency.
Liu S. (2009)
3 more