› 3peh

X-ray diffraction
2.75Å resolution

Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative

Released:
DOI: 10.2210/pdb3peh/pdb
PDB entry 3peh coloured by chain, front view.
PDB entry 3peh coloured by chain, side view.
PDB entry 3peh coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Tempel W, Hutchinson A, Weadge J, Cossar D, MacKenzie F, Vedadi M, Senisterra G, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Wyatt PG, Fairlamb AH, MacKenzie C, Ferguson MAJ, Hui R, Pizarro JC, Hills T, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-184626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine kinase/HSP90-like ATPase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 281 amino acids
Theoretical weight: 32.07 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I0V4 (Residues: 68-330; Coverage: 33%)
Gene name: PF3D7_1222300
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IBD 2 x IBD
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P42212
Unit cell:
a: 91.927Å b: 91.927Å c: 162.884Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.263
Expression system: Escherichia coli

Quick links