› 3pfs

X-ray diffraction
1.9Å resolution

PWWP Domain of Human Bromodomain and PHD finger-containing protein 3

Released:
DOI: 10.2210/pdb3pfs/pdb
PDB entry 3pfs coloured by chain, front view.
PDB entry 3pfs coloured by chain, side view.
PDB entry 3pfs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and histone binding ability characterizations of human PWWP domains.
Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, Min J
PLoS One 6 e18919 (2011)
PMID: 21720545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain and PHD finger-containing protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 158 amino acids
Theoretical weight: 18.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9ULD4 (Residues: 1056-1195; Coverage: 12%)
Gene names: BRPF3, KIAA1286
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 68.412Å b: 134.522Å c: 30.226Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.259
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

28 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
27 more

3 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
2 more