› 3po9

X-ray diffraction
2.35Å resolution

Crystal structure of PPARgamma ligand binding domain in complex with tripropyltin

Released:
DOI: 10.2210/pdb3po9/pdb
PDB entry 3po9 coloured by chain, front view.
PDB entry 3po9 coloured by chain, side view.
PDB entry 3po9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: le Maire A, Bourguet W

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 224-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand XPT 2 x XPT
Ligand PGO 4 x PGO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 93.406Å b: 61.747Å c: 118.659Å
α: 90° β: 102.91° γ: 90°
R-values:
R R work R free
0.204 0.201 0.269
Expression system: Escherichia coli

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