› 3pom

X-ray diffraction
2.5Å resolution

Crystal Structure of the Unliganded Retinoblastoma Protein Pocket Domain

Released:
DOI: 10.2210/pdb3pom/pdb
PDB entry 3pom coloured by chain, front view.
PDB entry 3pom coloured by chain, side view.
PDB entry 3pom coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the unliganded retinoblastoma protein pocket domain.
Balog ER, Burke JR, Hura GL, Rubin SM
Proteins 79 2010-4 (2011)
PMID: 21491492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoblastoma-associated protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 41.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06400 (Residues: 380-577, 643-787; Coverage: 37%)
Gene name: RB1
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 60.282Å b: 111.164Å c: 138.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.262
Expression system: Escherichia coli BL21(DE3)

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Citations

9 citation in other articles

Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division.
Desvoyes et al. (2014)
8 more

6 mentions without citation

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.
Burke et al. (2012)
5 more