› 3pry

X-ray diffraction
2.28Å resolution

Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution

Released:
DOI: 10.2210/pdb3pry/pdb
PDB entry 3pry coloured by chain, front view.
PDB entry 3pry coloured by chain, side view.
PDB entry 3pry coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Pilka E, Sharpe TD, Cooper CDO, Phillips C, Berridge G, Ayinampudi V, Fedorov O, Keates T, Thangaratnarajah C, Zimmermann T, Vollmar M, Yue WW, Che KH, Krojer T, Muniz JRC, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-beta Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 268 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08238 (Residues: 284-543; Coverage: 36%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB
Sequence domains: Hsp90 protein
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 1 x GOL
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P31
Unit cell:
a: 73.71Å b: 73.71Å c: 149.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.217
Expression system: Escherichia coli BL21(DE3)

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