› 3ps5

X-ray diffraction
3.1Å resolution

Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1

Released:
DOI: 10.2210/pdb3ps5/pdb
PDB entry 3ps5 coloured by chain, front view.
PDB entry 3ps5 coloured by chain, side view.
PDB entry 3ps5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation.
Wang W, Liu L, Song X, Mo Y, Komma C, Bellamy HD, Zhao ZJ, Zhou GW
J Cell Biochem 112 2062-71 (2011)
PMID: 21465528

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-151411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 67.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29350 (Residues: 1-595; Coverage: 100%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: R32
Unit cell:
a: 231.919Å b: 231.919Å c: 78.852Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.225 0.276
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling.
Kim et al. (2018)
10 more

14 mentions without citation

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?
Collins et al. (2012)
13 more