› 3pvn

X-ray diffraction
1.98Å resolution

Triclinic form of Human C-Reactive Protein in complex with Zinc

Released:
DOI: 10.2210/pdb3pvn/pdb
PDB entry 3pvn coloured by chain, front view.
PDB entry 3pvn coloured by chain, side view.
PDB entry 3pvn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A staggered decameric assembly of human C-reactive protein stabilized by zinc ions revealed by X-ray crystallography.
Guillon C, Bigouagou UM, Folio C, Jeannin P, Delneste Y, Gouet P
Protein Pept Lett 22 248-55 (2014)
PMID: 25552313

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 40 x CA
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 79.3Å b: 96.4Å c: 160.4Å
α: 79.9° β: 77.1° γ: 69.4°
R-values:
R R work R free
0.192 0.176 0.236
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Anti-Pentraxin Antibodies in Autoimmune Diseases: Bystanders or Pathophysiological Actors?
Brilland et al. (2020)
1 more

4 mentions without citation

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains.
Salzman et al. (2016)
3 more