› 3pzz

X-ray diffraction
1.29Å resolution

Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta

Released:
DOI: 10.2210/pdb3pzz/pdb
PDB entry 3pzz coloured by chain, front view.
PDB entry 3pzz coloured by chain, side view.
PDB entry 3pzz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for amyloid-beta polymorphism.
Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D
Proc Natl Acad Sci U S A 108 16938-43 (2011)
PMID: 21949245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138392 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 543 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 700-705; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 9.47Å b: 11.769Å c: 17.358Å
α: 99.83° β: 95.63° γ: 104.69°
R-values:
R R work R free
0.148 0.143 0.196
Expression system: Not provided

Quick links

Citations

39 review citations

The amyloid state of proteins in human diseases.
Eisenberg et al. (2012)
38 more

12 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
11 more