3q1s

X-ray diffraction
2.15Å resolution

HIV-1 neutralizing antibody Z13e1 in complex with epitope display protein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-212720 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Z13e1 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Z13e1 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Interleukin-22 Chain: I
Molecule details ›
Chain: I
Length: 151 amino acids
Theoretical weight: 17.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZX6 (Residues: 29-179; Coverage: 100%)
Gene names: IL22, ILTIF, UNQ3099/PRO10096, ZCYTO18
Sequence domains: Interleukin 22 IL-10-related T-cell-derived-inducible factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 56.623Å b: 99.216Å c: 105.533Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.207 0.26
Expression systems:
  • Not provided
  • Escherichia coli