› 3q2c

X-ray diffraction
2.5Å resolution

Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)

Released:
DOI: 10.2210/pdb3q2c/pdb
PDB entry 3q2c coloured by chain, front view.
PDB entry 3q2c coloured by chain, side view.
PDB entry 3q2c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.
Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF
PLoS One 6 e19245 (2011)
PMID: 21559424

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte immunoglobulin-like receptor subfamily A member 3 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N6C8 (Residues: 24-120; Coverage: 23%)
Gene names: ILT6, LILRA3, LIR4
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 83.308Å b: 27.817Å c: 48.257Å
α: 90° β: 111.65° γ: 90°
R-values:
R R work R free
0.226 0.225 0.257

Quick links

Citations

11 review citations

LILRB receptor-mediated regulation of myeloid cell maturation and function.
van der Touw et al. (2017)
10 more

2 mentions without citation

LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.
Ryu et al. (2011)
1 more