› 3q2x

X-ray diffraction
1.45Å resolution

Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta

Released:
DOI: 10.2210/pdb3q2x/pdb
PDB entry 3q2x coloured by chain, front view.
PDB entry 3q2x coloured by chain, side view.
PDB entry 3q2x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for amyloid-beta polymorphism.
Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D
Proc Natl Acad Sci U S A 108 16938-43 (2011)
PMID: 21949245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 616 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 698-703; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 15.074Å b: 4.838Å c: 24.016Å
α: 90° β: 95.56° γ: 90°
R-values:
R R work R free
0.21 0.204 0.259
Expression system: Not provided

Quick links

Citations

39 review citations

The amyloid state of proteins in human diseases.
Eisenberg et al. (2012)
38 more

10 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
9 more