› 3q32

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 35.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 839-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand J2I 2 x J2I
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P41
Unit cell:
a: 110.59Å b: 110.59Å c: 69.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.21
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Selective JAK inhibitors.
Dymock et al. (2014)
1 more

6 mentions without citation

Genomics and pharmacogenomics of dementia.
Cacabelos et al. (2011)
5 more